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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
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Halimane diterpenoids: sources, structures, nomenclature and biological activities
Alejandro M Roncero1, Ignacio E Tobal, Rosalina F Moro
1Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, Plaza de los Caidos 1-5, 37008 Salamanca, Spain. ismarcos@usal.es.
Natural Product Reports
|April 28, 2018
Summary
This review covers halimane diterpenoids, natural products with diverse biological activities including anticancer and antimicrobial properties. It classifies these compounds and reviews their synthesis, offering a comprehensive overview.
Area of Science:
- Natural Product Chemistry
- Organic Synthesis
- Biochemistry
Background:
- Halimane diterpenoids are a distinct class of natural products situated biogenetically between labdane and clerodane diterpenoids.
- These compounds exhibit a range of significant biological activities, including anticancer, antimicrobial, and germination inhibition.
- They also serve as potential biomarkers for tuberculosis.
Purpose of the Study:
- To provide the first comprehensive review of halimane skeleton diterpenoids.
- To classify these compounds based on their biogenetic origin, characterization, and biosynthesis.
- To review the existing synthetic strategies and approaches for halimane diterpenoids.
Main Methods:
- Literature review covering publications from 1970 to 2017.
- Systematic classification of halimane diterpenoids.
- Analysis of biosynthetic pathways and enzymatic involvement.
- Compilation and discussion of reported synthetic routes.
Main Results:
- A detailed classification of halimane diterpenoids is presented.
- The review consolidates information on their characterization and biosynthesis.
- Key synthetic methodologies and challenges are discussed.
Conclusions:
- Halimane diterpenoids represent a unique and biologically relevant class of natural products.
- This review serves as a foundational resource for researchers in natural product chemistry and synthetic organic chemistry.
- Further research into their biosynthesis and synthetic accessibility is warranted.
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