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A Sensitive Gold Nanoplasmonic SERS Quantitative Analysis Method for Sulfate in Serum Using Fullerene as Catalyst
Chongning Li1,2, Libing Wang3, Yanghe Luo4
1Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection, (Guangxi Normal University), Ministry of Education, Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin 541004, China. lcn7882342@163.com.
Nanomaterials (Basel, Switzerland)
|April 28, 2018
Summary
Fullerene catalyzes gold nanoparticle formation for enhanced Raman scattering (SERS) detection. This method quantifies sulfate in serum by observing SERS signal recovery upon sulfate binding with barium ions.
Area of Science:
- Nanomaterials Science
- Analytical Chemistry
- Spectroscopy
Background:
- Fullerene's catalytic properties are explored for nanomaterial synthesis.
- Surface-enhanced Raman scattering (SERS) is a sensitive detection technique.
- Developing new analytical methods for biological samples is crucial.
Purpose of the Study:
- To investigate fullerene's role in gold nanoplasmon formation for SERS.
- To develop a novel SERS-based method for sulfate detection.
- To establish a quantitative analysis of sulfate in serum samples.
Main Methods:
- Utilizing fullerene to catalyze the formation of gold nanoparticles (AuNPs).
- Employing Vitoria blue B as a probe molecule for SERS measurements.
- Investigating the effect of barium ions (Ba2+) and sulfate ions (SO42-) on the SERS signal.
Main Results:
- Fullerene concentration linearly correlated with SERS peak intensity due to AuNP formation.
- Barium ions inhibited fullerene catalysis, decreasing the SERS signal.
- Sulfate ions released inhibited fullerene, recovering catalysis and increasing SERS intensity linearly.
Conclusions:
- A new SERS quantitative analysis method for sulfate detection was established.
- The method demonstrated a linear detection range of 0.03–3.4 μM for sulfate.
- This approach offers a sensitive and specific way to analyze sulfate in serum samples.
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