Cardiac rehabilitation fitness changes and subsequent survival

Alban De Schutter1, Sergey Kachur2, Carl J Lavie1

  • 1John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA, USA.

Insights

Patients with coronary heart disease who show little or no improvement in cardiorespiratory fitness after cardiac rehabilitation face significantly higher mortality risks. Strategies are needed to enhance fitness gains and reduce non-response to cardiac rehabilitation.

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Public Health

Background:

  • Cardiac rehabilitation (CR) is crucial for managing coronary heart disease (CHD).
  • Traditional assessments often aggregate outcomes, potentially masking disparities in patient response.
  • Stratifying patients by cardiorespiratory fitness (CRF) improvement offers deeper insights into CR effectiveness.

Purpose of the Study:

  • To analyze the characteristics and prognosis of patients completing CR, stratified by CRF improvement.
  • To identify predictors of non-response (NonRes) and low-response (LowRes) to CR.
  • To compare mortality rates among NonRes, LowRes, and high-responders (HighRes) post-CR.

Main Methods:

  • 1171 CHD patients undergoing phase II CR were assessed using cardiopulmonary exercise testing before and after the program.
  • Patients were categorized into NonRes, LowRes, and HighRes based on absolute CRF improvement (peak oxygen consumption).
  • Mortality was analyzed over a mean follow-up of 6.4 years, with adjustments for key clinical and demographic factors.

Main Results:

  • 23% of patients were classified as NonRes.
  • Adjusted analyses revealed significantly higher mortality in NonRes (22%) and LowRes (17%) compared to HighRes (8%).
  • Predictors of poor CRF response included age, female gender, baseline CRF, hostility, diabetes, and higher waist circumference.

Conclusions:

  • A substantial proportion of CHD patients experience minimal CRF gains from CR, associated with elevated mortality.
  • Targeted interventions are necessary to improve CRF outcomes and mitigate risks for NonRes and LowRes.
  • Enhanced CR strategies should focus on optimizing fitness improvements to reduce long-term mortality in CHD patients.
Abstract

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