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Updated: Feb 11, 2026

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
Published on: April 19, 2019
Cardiac rehabilitation fitness changes and subsequent survival
Alban De Schutter1, Sergey Kachur2, Carl J Lavie1
1John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA, USA.
Insights
Patients with coronary heart disease who show little or no improvement in cardiorespiratory fitness after cardiac rehabilitation face significantly higher mortality risks. Strategies are needed to enhance fitness gains and reduce non-response to cardiac rehabilitation.
Area of Science:
- Cardiology
- Exercise Physiology
- Public Health
Background:
- Cardiac rehabilitation (CR) is crucial for managing coronary heart disease (CHD).
- Traditional assessments often aggregate outcomes, potentially masking disparities in patient response.
- Stratifying patients by cardiorespiratory fitness (CRF) improvement offers deeper insights into CR effectiveness.
Purpose of the Study:
- To analyze the characteristics and prognosis of patients completing CR, stratified by CRF improvement.
- To identify predictors of non-response (NonRes) and low-response (LowRes) to CR.
- To compare mortality rates among NonRes, LowRes, and high-responders (HighRes) post-CR.
Main Methods:
- 1171 CHD patients undergoing phase II CR were assessed using cardiopulmonary exercise testing before and after the program.
- Patients were categorized into NonRes, LowRes, and HighRes based on absolute CRF improvement (peak oxygen consumption).
- Mortality was analyzed over a mean follow-up of 6.4 years, with adjustments for key clinical and demographic factors.
Main Results:
- 23% of patients were classified as NonRes.
- Adjusted analyses revealed significantly higher mortality in NonRes (22%) and LowRes (17%) compared to HighRes (8%).
- Predictors of poor CRF response included age, female gender, baseline CRF, hostility, diabetes, and higher waist circumference.
Conclusions:
- A substantial proportion of CHD patients experience minimal CRF gains from CR, associated with elevated mortality.
- Targeted interventions are necessary to improve CRF outcomes and mitigate risks for NonRes and LowRes.
- Enhanced CR strategies should focus on optimizing fitness improvements to reduce long-term mortality in CHD patients.
Aims:
Assessments of cardiac rehabilitation (CR) in coronary heart disease (CHD) cohorts usually examine mortality in aggregate. This study examines the prognosis and characteristics of patients who enrolled and completed CR, stratified by their level of improvement in cardiorespiratory fitness (CRF) by examining the characteristics, outcomes and predictors of non-response in CRF (NonRes) compared with low-responders (LowRes) and high-responders (HighRes) after CR.
Methods And Results:
A total of 1171 CHD patients were referred for a phase II CR programme after therapy for an acute coronary syndrome, coronary artery bypass graft procedure or a percutaneous coronary intervention between 1 January 2000 and 30 June 2013 underwent cardiopulmonary exercise testing before and after CR. This cohort was divided according to absolute improvements in CRF (i.e. change in peak oxygen consumption expressed in mL⋅kg-1⋅min-1). Mortality was analysed after 0.5-13.4 years of follow-up (mean 6.4 years). A total of 266 (23%) subjects were NonRes. After adjustment for body mass index, age, gender, left ventricular ejection fraction and baseline CRF, NonRes, and LowRes had a statistically significant three-fold and two-fold higher mortality, respectively, when compared with HighRes (HighRes 8% vs. LowRes 17% vs. NonRes 22%; P < 0.001). Age, female gender, baseline CRF, hostility, and presence of diabetes were significant predictors of NonRes and LowRes. In addition, higher waist circumference was a predictor of NonRes.
Conclusion:
Significant proportions of subjects referred to CR have no/low improvement in CRF and higher associated mortality risks. Greater attention is required to increase improvements in CRF following CR and avoid NonRes.
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