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A Microneedle Patch for Measles and Rubella Vaccination Is Immunogenic and Protective in Infant Rhesus Macaques

Jessica C Joyce1, Timothy D Carroll2, Marcus L Collins3

  • 1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta.

The Journal of Infectious Diseases
|April 28, 2018
PubMed
Abstract

Insights

Microneedle (MN) patches effectively deliver measles-rubella (MR) vaccines, inducing protective antibody levels and complete protection against measles virus challenge in infant rhesus macaques. This novel approach offers a promising alternative for global MR vaccination efforts.

Area of Science:

  • Vaccinology
  • Immunology
  • Biotechnology

Background:

  • Global measles and rubella (MR) elimination goals require improved vaccination coverage.
  • Current vaccination methods face challenges including cold chain requirements and biohazardous waste.

Purpose of the Study:

  • To develop and evaluate microneedle (MN) patches for MR vaccine delivery.
  • To assess the immunogenicity and protective efficacy of MR vaccine delivered via MN patches in infant rhesus macaques.

Main Methods:

  • Development of MR vaccine-loaded MN patches.
  • Administration of MR vaccine via MN patches and subcutaneous (SC) injection in infant rhesus macaques.
  • Evaluation of neutralizing antibody titers and protection against wild-type measles virus challenge.

Main Results:

  • 100% of macaques receiving the MR vaccine via MN patches achieved protective measles antibody titers, compared to 75% in the SC group.
  • All macaques in the MN group were protected from measles virus challenge, versus 75% in the SC group.
  • MN and SC vaccination did not overcome simulated maternal antibody interference.

Conclusions:

  • MR vaccine delivered by MN patches generates protective immune responses in infant rhesus macaques.
  • MN patches provide a viable, needle-free alternative for MR vaccination, potentially improving global coverage.
  • Further research is needed to address challenges like maternal antibody interference.

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