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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
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Photoresponsive Drug/Gene Delivery Systems
Yang Zhou1, Huan Ye1, Yongbing Chen2
1Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology , Soochow University , Suzhou 215123 , China.
Biomacromolecules
|April 28, 2018
Summary
Photoresponsive systems offer precise control over drug and gene delivery using light. This review covers direct and indirect light-activated systems for enhanced therapeutic outcomes and safety.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmacology
Background:
- Light offers precise control over external stimuli like time, site, wavelength, and density.
- Photoresponsive drug/gene delivery systems are crucial for spatiotemporal control, enhancing therapeutic efficacy and safety.
Purpose of the Study:
- To review recent advancements in photoresponsive drug/gene delivery systems.
- To categorize and discuss different types of photoresponsive delivery mechanisms.
Main Methods:
- Summarized research on direct photoresponsive systems (vehicle/drug photoreactions).
- Detailed indirect photoresponsive systems triggered by light-generated mediators (heat, ROS, hypoxia, gas).
- Compiled materials and chemical structures responsive to UV, visible, and NIR light.
Main Results:
- Identified two major categories: direct and indirect photoresponsive systems.
- Highlighted various materials and structures for UV, visible, and NIR light responsiveness.
- Emphasized the role of mediators like heat, ROS, hypoxia, and gas in indirect systems.
Conclusions:
- Photoresponsive systems provide advanced spatiotemporal control for drug/gene delivery.
- Direct and indirect systems offer distinct mechanisms for light-triggered release.
- Future research should address challenges and explore new applications in this field.
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