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Updated: Feb 11, 2026
Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium
Published on: July 8, 2015
Scalable Synthesis of Mycocyclosin
Xu Zhu1, Christopher C McAtee1, Corinna S Schindler1
1Department of Chemistry, Willard Henry Dow Laboratory , University of Michigan , 930 North University Avenue , Ann Arbor , Michigan 48109 , United States.
Abstract:
We report herein the scalable total synthesis of the secondary metabolite, mycocyclosin, initially isolated from Mycobacterium tuberculosis. Mycocylosin bears a highly strained 3,3'-dityrosine biaryl system which arises biosynthetically from an intramolecular oxidative dehydrogenative cross-coupling of cyclo(l-Tyr-l-Tyr) (cYY) catalyzed by the P450 enzyme CYP121. CYP121 is found exclusively in M. tuberculosis. Scalable access to mycocyclosin and related derivatives via a Pd(II)-catalyzed macrocyclization is anticipated to facilitate the biological evaluation of these compounds as novel tuberculosis antimicrobials.
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