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Related Concept Videos

Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
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A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
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Percutaneous Ablation for Hepatocellular Carcinoma.

Jeffrey L Weinstein1, Muneeb Ahmed1

  • 11 Division of Vascular and Interventional Radiology, Department of Radiology, WCC 308-F, Beth Israel Deaconess Medical Center/Harvard Medical School, 1 Deaconess Rd, Boston, MA 02215.

AJR. American Journal of Roentgenology
|April 28, 2018
PubMed
Summary

Percutaneous ablation is a key treatment for early-stage hepatocellular carcinoma (HCC), providing survival rates similar to surgery for small tumors. Advanced techniques and combination therapies enhance outcomes for larger lesions.

Keywords:
ablationhepatocellular carcinomapercutaneousradiofrequency

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Area of Science:

  • Hepatobiliary Medicine
  • Interventional Oncology
  • Minimally Invasive Therapies

Background:

  • Hepatocellular carcinoma (HCC) is a primary liver cancer with significant global impact.
  • Treatment options for HCC range from curative therapies to palliative care, depending on stage.
  • Percutaneous ablation has emerged as a crucial modality in HCC management.

Purpose of the Study:

  • To review the application of percutaneous ablation for hepatocellular carcinoma (HCC).
  • To compare the efficacy of percutaneous ablation with other treatment modalities.
  • To discuss technical aspects and future directions in HCC ablation therapy.

Main Methods:

  • Literature review of studies on percutaneous ablation for HCC.
  • Comparative analysis of survival outcomes for different HCC treatments.
  • Discussion of technical considerations for ablation procedures.

Main Results:

  • Percutaneous ablation offers survival comparable to surgical resection for early-stage HCC with small lesions.
  • Ablation can serve as a curative treatment or a bridge to liver transplantation.
  • Newer ablation techniques and combination therapies improve outcomes and expand treatment eligibility.

Conclusions:

  • Percutaneous ablation is a cornerstone therapy for early-stage HCC.
  • Combination therapies, including transarterial chemoembolization, enhance treatment effectiveness.
  • Future research focuses on combining thermal ablation with systemic therapies like immunotherapy.