Related Experiment Video
Updated: Feb 11, 2026

The Polyvinyl Alcohol Sponge Model Implantation
Published on: April 18, 2012
Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis
Amr El-Demerdash1,2, Céline Moriou3, Jordan Toullec4
1Institut de Chimie des Substances Naturelles, CNRS UPR 2301, University Paris-Sud, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France. eldemerdash555@gmail.com.
Abstract:
Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2⁻9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively.
Related Concept Videos
Measurement: Derived Units
Higher Derivatives
Derivatives
The Derivative as a Function
Derivatives: Problem Solving
First Derivative Test: Problem Solving

