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Wheezing phenotypes and risk factors in early life: The ELFE cohort

Souheil Hallit1, Benedicte Leynaert2,3, Marie Christine Delmas4

  • 1U1219 INSERM, ISPED, Bordeaux University, Bordeaux, France.

Plos One
|April 28, 2018
PubMed

Insights

Infants with respiratory symptoms like cough and distress are at higher risk for persistent wheezing. Maternal smoking during pregnancy is also a risk factor for infant wheezing phenotypes.

Area of Science:

  • Pediatrics
  • Epidemiology
  • Respiratory Medicine

Background:

  • Wheezing phenotypes in early life are not well-defined.
  • Understanding these phenotypes is crucial for early intervention.

Purpose of the Study:

  • To describe wheezing phenotypes in infants aged two months to one year.
  • To identify risk factors associated with these phenotypes in a large birth cohort.

Main Methods:

  • Analysis of 18,041 infants from the French Longitudinal Study of Children (ELFE) birth cohort.
  • Parental reporting of wheezing and respiratory symptoms at two and 12 months.
  • Questionnaires on prenatal exposures and parental allergies.

Main Results:

  • 18.3% of infants had incident wheezing, 2.4% had persistent wheezing.
  • Risk factors for persistent wheezing included siblings, nocturnal cough, respiratory distress, excess bronchial secretions, reflux, maternal asthma history, and maternal smoking.
  • Maternal smoking during pregnancy was linked to both persistent and incident wheezing.

Conclusions:

  • Respiratory symptoms in infancy are significant predictors of persistent wheezing.
  • Prenatal smoke exposure is a key risk factor for developing wheezing phenotypes.
Abstract

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