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Updated: Feb 11, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Economic Burden of Individual Suffering from Atrial Fibrillation-Related Stroke in China
Shanlian Hu1, Lin Zhan2, Bao Liu3
1Shanghai Health Development Research Center, Shanghai, PR China; School of Public Health, Fudan University, Shanghai, PR China.
Insights
The 1-year cost of stroke in Chinese patients with atrial fibrillation (AF) is substantial, driven mainly by hospitalization expenses. Optimal management of AF is crucial for preventing costly strokes.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Health Economics
Background:
- Atrial fibrillation (AF) is a significant risk factor for ischemic stroke.
- Understanding the economic burden of AF-related stroke is crucial for healthcare planning in China.
Purpose of the Study:
- To estimate the 1-year direct and indirect costs of ischemic stroke in Chinese patients diagnosed with atrial fibrillation.
Main Methods:
- A retrospective chart review of 300 patients with ischemic stroke and AF from 18 hospitals across six Chinese cities.
- Prospective 1-year follow-up of 63 selected patients to record resource utilization and work absenteeism.
Main Results:
- The mean total direct cost was 30,438.3 CNY per patient-year, with acute hospitalization being the primary cost driver (61.5%).
- Indirect costs, mainly from early retirement, averaged 16,838.9 CNY per person-year for those under retirement age.
- Factors like higher hospital ranking, longer stay, stroke severity, surgery, thrombolysis, and complications increased inpatient costs.
Conclusions:
- Hospitalization costs significantly contribute to the total direct cost of AF-related stroke in China, reflecting the current hospital-centered care model.
- AF-induced strokes are largely preventable, underscoring the need for improved clinical management and stroke prevention strategies in AF patients.
Objective:
Atrial fibrillation (AF) is an important risk factor for stroke. The primary purpose of this study was to estimate the 1-year direct and indirect costs of ischemic stroke in Chinese patients with AF.
Method:
A total of 300 charts were selected and reviewed in 18 hospitals from neurology departments in six major cities of China nationwide. Patients with primary diagnosis of ischemic stroke and secondary diagnosis of AF were selected for review. A total of 63 patients were selected from the chart review pool and followed up for 1 year to record their resource utilization and absenteeism from work following discharge.
Results:
The mean±SD age of the cohort was 70.2±11.8 years, with an average hospitalization duration of stay of 17.9 days. The mean total direct cost for AF-related stroke was estimated at 30,438.3 China Yuan (CNY) per patient-year. The major cost driver for direct cost was stroke's acute hospitalization expense, which accounted for 61.5% (CNY 18,706.1). Among the seven patients not reaching the legal retirement age, the indirect cost per person-year totaled 16,838.9 CNY, most of which (63.0%) was a result of early retirement. The analysis also suggested that higher hospital ranking (based on the tier system), longer hospital stay, higher modified Rankin Scale score, taking surgery during hospitalization, receiving thrombolysis therapy, and incidence of complications such as pneumonia or cerebral edema predicted higher inpatient costs.
Conclusions:
Hospital costs due to strokes among patients with AF are the predominant contributor to the total direct cost, which is consistent with current hospital-centered treatment pattern in China. However, literature suggested that AF-induced strokes are highly preventable with drugs and clinical procedures, which highlights the importance of optimal clinical management of stroke prevention in patients with AF.
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