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Hepatic veno-occlusive disease related to Gynura segetum: A case report

Ziyi Sun1,2, Jianmei Kang3, Yongchang Zhang1

  • 1Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya School of Medicine.

Medicine
|April 29, 2018
PubMed

Insights

Hepatic veno-occlusive disease (HVOD) can be caused by Gynura segetum ingestion. Portal flow reversal on imaging is a key diagnostic sign, and liver transplantation is crucial for severe cases.

Area of Science:

  • Hepatology
  • Toxicology
  • Radiology

Background:

  • Hepatic veno-occlusive disease (HVOD), also known as hepatic sinusoidal obstruction syndrome (HSOS), is a severe liver condition.
  • It involves damage to liver sinusoidal endothelial cells, leading to blocked hepatic venules and significant mortality.
  • The condition can arise from various causes, including toxin exposure.

Observation:

  • A case study of HVOD following one month of Gynura segetum ingestion is presented.
  • The patient exhibited symptoms of abdominal pain and distension.
  • Diagnosis was confirmed using CT and liver ultrasonography.

Findings:

  • Portal flow reversal was identified as a characteristic imaging finding in this HVOD case.
  • This finding is proposed as a specific diagnostic criterion for HVOD.
  • The patient received best supportive care but ultimately succumbed to the disease.

Implications:

  • Early recognition of portal flow reversal on imaging can aid in HVOD diagnosis.
  • Prompt consideration of liver transplantation is vital for patients with worsening HVOD.
  • Understanding toxicological causes like Gynura segetum is crucial for prevention.
Abstract

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