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Significance of asymptomatic hyperuricemia in patients after coronary events

Ivan Tasić1,2, Svetlana Kostić2, Nikola M Stojanović3

  • 1a Department of Internal Medicine, Faculty of Medicine , University of Niš , Niš , Serbia.

Scandinavian Journal of Clinical and Laboratory Investigation
|April 29, 2018
PubMed

Insights

Asymptomatic hyperuricemia in coronary artery disease (CAD) patients is linked to more risk factors and poorer heart function, but not necessarily to severe CAD. Serum uric acid levels correlate with BMI, triglycerides, creatinine, and ejection fraction.

Area of Science:

  • Cardiology
  • Metabolic Syndrome

Background:

  • Hyperuricemia, indicated by elevated serum uric acid (SUA) levels, is increasingly recognized as a potential contributor to cardiovascular disease.
  • Understanding the prevalence and implications of hyperuricemia in patients with established coronary artery disease (CAD) is crucial for risk stratification and management.

Purpose of the Study:

  • To determine the prevalence of hyperuricemia in patients with CAD within three months post-coronary events.
  • To investigate the correlation between hyperuricemia and the severity of CAD, overall heart function, and cardiovascular risk factors.

Main Methods:

  • The study included 505 consecutive CAD patients (385 males, 120 females) aged 60.9 ± 9.6 years, admitted for cardiovascular rehabilitation post-acute myocardial infarction (AMI).
  • Serum uric acid (SUA) levels were measured, and patients were assessed for cardiovascular risk factors, CAD severity, and heart function (ejection fraction - EF).
  • Multivariate stepwise analysis was employed to identify predictors of SUA levels.

Main Results:

  • A total of 115 patients (22.8%) presented with asymptomatic hyperuricemia.
  • Patients with asymptomatic hyperuricemia exhibited a higher average number of risk factors, lower HDL cholesterol, elevated creatinine and triglyceride levels, and reduced ejection fraction (EF).
  • Multivariate analysis identified BMI, triglyceride levels, creatinine levels, and EF as independent predictors of SUA levels.

Conclusions:

  • Serum uric acid levels in CAD patients are independently associated with BMI, triglyceride and creatinine levels, and negatively with ejection fraction.
  • Asymptomatic hyperuricemia is not significantly associated with the severity of coronary artery disease in this cohort.

Keywords:
Uric acidasymptomatic hyperuricemiacoronary artery diseaseischemic heart diseasemyocardial infarction

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