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Related Experiment Video

Updated: Feb 11, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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First-line therapy in relapsing remitting multiple sclerosis.

D Biotti1, J Ciron1

  • 1Pole des neurosciences, B4 Neurology unit, CHU de Purpan, Toulouse, France.

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|April 29, 2018
PubMed
Summary

First-line multiple sclerosis treatments, including injectables and oral options like teriflunomide and dimethyl fumarate, offer similar effectiveness and reassuring safety profiles. Early intervention with these therapies improves quality of life and reduces disease activity.

Keywords:
FumaratesGlatiramer acetateInterferonMultiple sclerosisTeriflunomideTreatment

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Area of Science:

  • Neurology
  • Immunology

Background:

  • Current first-line multiple sclerosis (MS) treatments include long-standing injectable immunomodulators and newer oral agents such as teriflunomide and dimethyl fumarate.
  • These therapies have demonstrated comparable efficacy and generally favorable safety profiles.

Purpose of the Study:

  • To review current first-line multiple sclerosis treatments available in France.
  • To discuss the effectiveness, safety, and specific considerations for pediatric patients and women planning pregnancy.

Main Methods:

  • Review of existing clinical data and treatment guidelines.
  • Analysis of effectiveness and safety profiles of available first-line MS therapies.

Main Results:

  • First-line MS treatments reduce radiological and clinical disease activity.
  • Early treatment initiation positively impacts patient quality of life.

Conclusions:

  • Teriflunomide and dimethyl fumarate represent advancements in oral MS treatment options.
  • Further consideration is needed for specific populations, including pediatric MS and women of childbearing potential.