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Features and roles of T helper 9 cells and interleukin 9 in immunological diseases

R Yazdani1, S Shapoori2, M Rezaeepoor2

  • 1Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran.

Allergologia Et Immunopathologia
|April 29, 2018
PubMed

T helper 9 (TH9) cells are considered as newly classified helper T cells that have an important role in the regulation of immune responses. Since these cells preferentially produce IL-9, these cells are termed TH9 cells. Recently, the role of TH9 and its signature cytokine (IL-9) has been investigated in a wide range of diseases, including autoimmunity, allergy, infections, cancer and immunodeficiency. Herein, we review the most recent data concerning TH9 cells and IL-9 as well as their roles in disease. These insights suggest that TH9 cells are a future target for therapeutic intervention.

Keywords:
AllergicAutoimmunityCancerIL-9ImmunodeficiencyInfectionsT(H)9 cells

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