Case-Cohort Studies: Design and Applicability to Hand Surgery
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Updated: Feb 11, 2026

Design, Fabrication, and Administration of the Hand Active Sensation Test HASTe
Published on: September 8, 2015
Miliana Vojvodic1, Mark Shafarenko2, Steven J McCabe3
1Division of Plastic and Reconstructive Surgery, Department of Surgery, University Health Network Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Abstract:
Observational studies are common research strategies in hand surgery. The case-cohort design offers an efficient and resource-friendly method for risk assessment and outcomes analysis. Case-cohorts remain underrepresented in upper extremity research despite several practical and economic advantages over case-control studies. This report outlines the purpose, utility, and structure of the case-cohort design and offers a sample research question to demonstrate its value to risk estimation for adverse surgical outcomes. The application of well-designed case-cohort studies is advocated in an effort to improve the quality and quantity of observational research evidence in hand and upper extremity surgery.
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