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Updated: Feb 11, 2026

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
Published on: May 10, 2017
Visual stimulation leads to activation of the nociceptive trigeminal nucleus in chronic migraine
Laura H Schulte1, Angie Allers1, Arne May2
1From the Department of Systems Neuroscience, University Medical Center Eppendorf, Hamburg, Germany.
Objective:
The visual system has often been described to be sensitized in migraineurs, with light being perceived as aversive or even painful. One possible explanation for this altered perception is crosslinks between the visual and the trigeminonociceptive system. Visual stimulation in chronic migraineurs on the level of the brainstem might lead to enhanced activity within the spinal trigeminal nucleus (sTN) as the main site of trigeminal pain processing within this area.
Methods:
Eighteen episodic migraineurs (EM), 17 chronic migraineurs (CM), and 19 healthy controls (HC) underwent one session of high-resolution brainstem imaging during which a rotating checkerboard was presented repeatedly as a visual stimulus. Data were analyzed using SPM12 and MATLAB with the classic first-level-second-level approach of SPM. Analyses of variance were used for group comparisons.
Results:
CM showed enhanced activation within the sTN as compared to HC. In addition, we observed enhanced activity within the right superior colliculus in CM as compared to HC. When comparing all migraineurs with headaches during scanning with all migraineurs without headaches during scanning and HC, we also found the sTN to be more strongly activated during headaches.
Conclusion:
Our data provide evidence for the existence of visual-nociceptive integration on brainstem level in chronic migraineurs.
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