Related Experiment Video
Updated: Feb 11, 2026
08:45
Author Spotlight: Generation of and Comparison Between Patient-Derived Gastric Organoids from Different Regions of the Stomach
Published on: January 26, 2024
2.1K
Human gastric cancer modelling using organoids.
Therese Seidlitz1, Sebastian R Merker1, Alexander Rothe1
1Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Gut
|April 29, 2018
Summary
Gastric cancer organoids were developed to model human disease and test drug responses. These models accurately reflect patient tumors and can predict treatment effectiveness, guiding personalized gastric cancer therapy.
Area of Science:
- Oncology
- Gastroenterology
- Translational Medicine
Background:
- Gastric cancer is a leading cause of cancer mortality globally.
- Effective treatment strategies are needed to improve patient outcomes.
Purpose of the Study:
- To develop and characterize human and mouse gastric cancer organoids.
- To utilize these organoids for drug testing and personalized therapy prediction.
Main Methods:
- Established and analyzed human gastric cancer organoid cultures.
- Classified organoids by molecular profile and tested responses to chemotherapeutics.
- Generated mouse gastric cancer organoids with specific mutations.
Main Results:
- Organoids mirrored primary tumor characteristics and molecular subtypes (microsatellite instable, genomic stable, chromosomal instable).
- Observed divergent responses to conventional chemotherapies.
- Demonstrated successful targeted therapy for specific mutations (e.g., trastuzumab for ERBB2, palbociclib for CDKN2A loss).
Conclusions:
- Human and mouse gastric cancer organoids effectively model the disease.
- Organoids serve as valuable living biomarkers for predicting therapy response.
Keywords:
gastric cancerMore Related Videos
Related Concept Videos
01:16Gastric Motility
3.2K
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
3.2K
01:16Gastric Emptying
3.9K
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
3.9K
01:26Gastric Phase of Digestion
3.5K
The gastric phase of digestion begins as soon as food enters the stomach. The incoming food bolus triggers neural and hormonal mechanisms, which last approximately 3 to 4 hours. During this phase, the stomach undergoes significant changes to prepare the food for further digestion and absorption.
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
3.5K
02:43Mouse Models of Cancer Study
6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
02:18Cancer
54.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.4K
02:12What is Cancer?
14.5K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.5K