Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

4.0K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
4.0K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

4.0K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
4.0K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.2K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.2K
Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
The Cell Cycle Control System01:28

The Cell Cycle Control System

5.6K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Jump-starting the T cell response in established tumors.

bioRxiv : the preprint server for biology·2026
Same author

Defective B cell tolerance in SLE lymph nodes underpins VH<sub>4-34</sub> "clonal damnation" and PD-1<sup>+</sup>TOX<sup>+</sup> autoreactive B cells expansion.

medRxiv : the preprint server for health sciences·2026
Same author

Six-Month Outcomes in Children With COVID-19 or Multisystem Inflammatory Syndrome in Children.

Hospital pediatrics·2026
Same author

Transcriptional programming of early-forming memory B cells arises independently of cognate CD4+ T-cell interactions.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Heme enhances B-cell proliferation and plasma cell formation through reduced p21 and Rb expression.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Upregulated ZBP1 Is Associated with B-Cell Dysregulation in Systemic Lupus Erythematosus.

Biomedicines·2026
Same journal

PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction.

Nature communications·2026
Same journal

PfApiAT2 is a proline transporter essential for the transmission of Plasmodium falciparum by the mosquito vector.

Nature communications·2026
Same journal

Transient distortions of the South Atlantic Anomaly radiation environments driven by electric fields.

Nature communications·2026
Same journal

Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase.

Nature communications·2026
Same journal

Structural and mechanistic insights into primer synthesis initiation by DNA primase.

Nature communications·2026
Same journal

Changes in heritability and shared environmentality of educational attainment across twentieth-century Norway.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

13.2K

Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs.

Christopher D Scharer1, Benjamin G Barwick2,3, Muyao Guo2,4

  • 1Department of Microbiology and Immunology, Emory University, Atlanta, GA, 30322, USA. cdschar@emory.edu.

Nature Communications
|April 29, 2018
PubMed
Summary
This summary is machine-generated.

This study maps epigenetic changes during B cell differentiation, revealing how cell division influences gene regulation. Inhibiting EZH2 promotes plasma cell formation and early Blimp-1 expression, key for humoral immunity.

More Related Videos

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
12:44

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells

Published on: October 11, 2012

24.0K
Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.6K

Related Experiment Videos

Last Updated: Feb 11, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

13.2K
Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
12:44

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells

Published on: October 11, 2012

24.0K
Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.6K

Area of Science:

  • Immunology
  • Epigenetics
  • Molecular Biology

Background:

  • The epigenetic and transcriptional regulation of B cell differentiation is not fully understood.
  • This knowledge gap hinders comprehension of humoral immune response development.

Purpose of the Study:

  • To define a cis-regulatory element roadmap during in vivo B cell differentiation.
  • To understand the interplay between cell division, chromatin accessibility, and gene expression.

Main Methods:

  • Utilized an in vivo T cell-independent B cell differentiation model.
  • Employed ATAC-seq to map chromatin accessibility changes.
  • Correlated chromatin accessibility with gene expression patterns.

Main Results:

  • Identified cell division-dependent changes in chromatin accessibility and gene expression.
  • Discovered a subset of naive B cell genes with accessible promoters marked by H3K27me3, including Blimp-1.
  • Showed that EZH2 inhibition enhances plasma cell formation and premature Blimp-1 expression.

Conclusions:

  • Cell division is coupled with epigenetic and transcriptional reprogramming during plasma cell development.
  • EZH2-mediated epigenetic regulation plays a critical role in controlling the timing of plasma cell differentiation.
  • These findings offer insights into the molecular mechanisms programming plasma cells.