Related Experiment Video

Updated: Feb 11, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

12.2K

Artemether attenuates LPS-induced inflammatory bone loss by inhibiting osteoclastogenesis and bone resorption via

Haobo Wu1,2, Bin Hu1,2, Xiaopeng Zhou1,2

  • 1Department of Orthopedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.

Cell Death & Disease
|April 29, 2018
PubMed

Insights

Artemether, a malaria drug, effectively suppresses osteoclast formation and bone erosion by inhibiting key signaling pathways. This natural compound shows potential for treating bone loss disorders.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Osteology

Background:

  • Osteolysis involves increased osteoclast activity and bone erosion, necessitating treatments that inhibit osteoclast differentiation and function.
  • Artemether, derived from Artemisia annua L., is primarily known for its antimalarial properties.

Purpose of the Study:

  • To investigate artemether's potential to suppress osteoclastogenesis and mitigate inflammatory bone loss.
  • To elucidate the molecular mechanisms underlying artemether's effects on osteoclasts.

Main Methods:

  • Assessing artemether's impact on RANKL-induced osteoclastogenesis and marker gene expression in vitro.
  • Evaluating artemether's inhibition of osteoclastic bone resorption and MAPKs (ERK, JNK, p-38) activity.
  • Testing artemether's efficacy in a murine model of LPS-induced inflammatory bone loss.

Main Results:

  • Artemether suppressed RANKL-induced osteoclastogenesis and key osteoclast marker genes.
  • The compound inhibited osteoclastic bone resorption and attenuated RANKL-induced MAPKs activation.
  • Artemether mitigated bone erosion in a murine model of inflammatory bone loss.

Conclusions:

  • Artemether reduces inflammatory bone loss by inhibiting MAPKs activation during osteoclast differentiation.
  • Artemether demonstrates potential as a therapeutic agent for osteoclast-related bone disorders.

More Related Videos

Models of Bone Metastasis08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.2K
Using Alizarin Red Staining to Detect Chemically Induced Bone Loss in Zebrafish Larvae05:03

Using Alizarin Red Staining to Detect Chemically Induced Bone Loss in Zebrafish Larvae

Published on: December 28, 2021

6.0K

Related Concept Videos

MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
8.5K
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.9K
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.8K
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.5K
The Hyoid Bone01:12

The Hyoid Bone

The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
5.2K