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Related Experiment Video

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Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue
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Three-dimensional Cardiomyocytes Structure Revealed By Diffusion Tensor Imaging and Its Validation Using a

Sang-Eun Lee1,2,3, Christopher Nguyen3,4,5, Jongjin Yoon6

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Diffusion tensor imaging (DTI) accurately maps cardiomyocyte orientation in the heart, validated by 3D histology. This technique shows reduced helix angle transmurality in heart failure, offering a promising noninvasive tool for cardiovascular disease research.

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Area of Science:

  • Biomedical Imaging
  • Cardiovascular Research
  • Histology

Background:

  • Cardiovascular diseases alter myocardial microstructure.
  • Accurate characterization of cardiomyocyte architecture is crucial for understanding heart function and disease.
  • Existing methods for assessing cardiomyocyte orientation can be invasive or lack 3D resolution.

Purpose of the Study:

  • To characterize the microstructural response of the myocardium to cardiovascular disease using diffusion tensor imaging (DTI).
  • To validate DTI findings with intact, three-dimensional (3D) histology using a tissue-clearing technique.
  • To assess the accuracy of DTI in quantifying cardiomyocyte orientation and transmurality.

Main Methods:

  • Diffusion tensor imaging (DTI) was performed on fixed ex-vivo mouse hearts (normal and ischemic heart failure models).
  • Hearts were processed using a tissue-clearing technique for intact 3D histological analysis.
  • Cardiomyocyte orientation, helix angle (HA), and global HA transmurality (HAT) were quantified and compared between DTI and 3D histology.

Main Results:

  • DTI successfully mapped cardiomyocyte orientation and was validated by 3D histology.
  • Global HAT was significantly reduced in the ischemic heart failure group compared to controls (p < 0.001).
  • Strong correlations were observed between DTI and 3D histology for cardiomyocyte orientation assessment (R²=0.803 per-sample, R²=0.872 per-segment).

Conclusions:

  • DTI is a capable and accurate tool for mapping cardiomyocyte orientation in the myocardium.
  • The study demonstrates the potential of DTI for noninvasive characterization of cardiac microstructure in disease states.
  • This approach provides valuable insights into the architectural changes associated with cardiovascular disease.