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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Use of Alu Element Containing Minigenes to Analyze Circular RNAs
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Different roles of circular RNAs with protein coding potentials.

Angshuman Bagchi1

  • 1Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, Nadia, 741235, India.

Biochemical and Biophysical Research Communications
|April 29, 2018
PubMed
Summary

Circular RNAs (ribonucleic acids) are novel non-coding RNAs that can produce proteins. This study analyzes the structural details of these circular RNA-derived proteins for the first time, revealing their molecular characteristics.

Keywords:
Circular RNALong non-coding RNAMolecular mechanismProtein codingStructural details

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Area of Science:

  • Molecular Biology
  • Genomics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are a distinct class of long non-coding RNAs known for their covalently closed structure and resistance to exonucleases.
  • circRNAs have been implicated in various human diseases.
  • While classified as non-coding, some circRNAs have been experimentally shown to generate protein products.

Purpose of the Study:

  • To investigate the structural aspects of proteins derived from circular RNAs.
  • To elucidate the molecular details of proteins translated from experimentally verified protein-coding circRNAs.

Main Methods:

  • Selection of circular RNAs with direct experimental evidence of protein production.
  • Analysis of the structural characteristics of the resulting protein products.

Main Results:

  • The study provides the first detailed molecular analysis of proteins translated from circular RNAs.
  • Identified specific structural features of these unique protein products.

Conclusions:

  • Circular RNA-derived proteins possess distinct molecular structures.
  • This research opens new avenues for understanding circRNA function and their role in disease.