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Understanding dengue virus evolution to support epidemic surveillance and counter-measure development
S Pollett1, M C Melendrez2, I Maljkovic Berry2
1Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Marie Bashir Institute, University of Sydney, NSW, Australia; Institute for Global Health Sciences, University of California at San Francisco, CA, USA.
Summary
Understanding Dengue virus (DENV) evolution aids in combating its rising global burden. Evolutionary analyses using sequencing and bioinformatics enhance DENV epidemic surveillance and response strategies.
Area of Science:
- * Arbovirology and Evolutionary Biology
- * Public Health and Epidemiology
Background:
- * Dengue virus (DENV) poses a significant global health threat, with increasing morbidity and mortality.
- * Co-circulation of four DENV serotypes is exacerbated by globalization, climate change, and vector range expansion.
- * Ae. aegypti and Ae. albopictus are key vectors implicated in DENV transmission.
Purpose of the Study:
- * To provide a scoping overview of DENV evolution and molecular epidemiology.
- * To highlight the application of evolutionary analyses as a public health tool against DENV.
- * To explore how advances in computational biology can improve DENV surveillance and response.
Main Methods:
- * Review of current literature on DENV evolution and molecular epidemiology.
- * Integration of RNA virus sequencing, bioinformatics, and phylogenetic methods.
- * Analysis of computational biology approaches for arboviral pathogen surveillance.
Main Results:
- * Evolutionary insights offer opportunities to enhance DENV surveillance and response.
- * Advances in sequencing and bioinformatics facilitate detailed molecular epidemiology.
- * Phylogenetic and computational methods are crucial for understanding DENV dynamics.
Conclusions:
- * Evolutionary analyses are vital for effective public health strategies against DENV.
- * Interdisciplinary approaches combining virology, epidemiology, and computational biology are essential.
- * Enhanced understanding of DENV evolution can mitigate epidemic impacts.
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