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Updated: Feb 11, 2026
11:50
Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
Published on: April 10, 2012
16.0K
MYB - A regulatory factor in hematopoiesis.
Xunde Wang1, Nikolaos Angelis1, Swee Lay Thein1
1National Heart, Lung and Blood Institute/NIH, Sickle Cell Branch, Bethesda, USA.
Gene
|April 29, 2018
Summary
The MYB transcription factor is crucial for cell survival and development. Targeting MYB offers potential therapeutic strategies for leukemia and beta-hemoglobinopathies by modulating gene expression.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MYB is a transcription factor with viral (v-MYB) and cellular (c-MYB) forms.
- c-MYB possesses distinct functional domains: DNA binding, transactivation, and negative regulation.
- c-MYB is vital for embryonic development and hematopoietic cell maturation.
Purpose of the Study:
- To investigate the role of MYB in cellular processes.
- To explore MYB as a potential therapeutic target.
Main Methods:
- Analysis of c-MYB structure and function.
- Examination of c-MYB expression patterns in various tissues.
- Review of recent studies implicating c-MYB in disease.
Main Results:
- c-MYB is essential for survival, with gene deletion causing embryonic lethality.
- High c-MYB expression is observed in hematopoietic, thymus, and neural tissues.
- Aberrant MYB expression is linked to various cancers, including leukemia.
- c-MYB influences fetal hemoglobin expression, relevant to beta-hemoglobinopathies.
Conclusions:
- MYB plays a critical role in normal development and cellular function.
- Aberrant MYB expression is implicated in oncogenesis and leukemia.
- MYB represents a promising therapeutic target for leukemia and beta-hemoglobinopathies.
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