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Systemic retinoid therapy for psoriasis.

N J Lowe1, V Lazarus, L Matt

  • 1Dermatology Program, University of California, Los Angeles School of Medicine 90024.

Journal of the American Academy of Dermatology
|July 1, 1988
PubMed
Summary
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Retinoids are effective treatments for severe psoriasis, including plaque and pustular forms. New retinoid analogs are being studied for psoriasis management, often in combination with therapies like phototherapy.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Retinoids are recognized for their therapeutic efficacy in various dermatological conditions.
  • Severe forms of psoriasis, including plaque and pustular types, often require potent treatment strategies.

Purpose of the Study:

  • To review the use of specific retinoids in managing severe psoriasis.
  • To discuss the application of retinoid analogs in dermatological therapy.

Main Methods:

  • Literature review of clinical investigations involving retinoids for psoriasis.
  • Analysis of retinoid efficacy in different psoriasis subtypes.

Main Results:

  • Retinoids demonstrate significant benefit in severe plaque psoriasis, particularly when combined with phototherapy.

Related Experiment Videos

  • Retinoids serve as effective monotherapy for generalized pustular psoriasis and aid in controlling exfoliative psoriasis.
  • Conclusions:

    • Etretinate, isotretinoin, acitretin, and arotinoid ethyl ester are key retinoids for severe psoriasis treatment.
    • The strategic use of retinoids, individually or in combination, is crucial for managing severe psoriatic conditions.