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The association of CCL3 and CCL4 polymorphisms with HCV clearance in Chinese Han population

Mei Liu1, Ming Yue2, Yinan Yao1

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

Gene
|April 30, 2018
PubMed

Insights

Genetic variants in CCL3 and CCL4 influence hepatitis C virus (HCV) treatment outcomes. Specific SNPs (rs1063340 and rs1049807) were linked to reduced sustained virologic response (SVR) in patients undergoing interferon therapy.

Area of Science:

  • Immunogenetics
  • Virology
  • Hepatology

Background:

  • Hepatitis C virus (HCV) infection poses a significant global health challenge.
  • Understanding host genetic factors influencing HCV clearance and treatment response is crucial for developing effective therapies.
  • Chemokine ligand genes, CCL3 and CCL4, play roles in immune responses relevant to viral infections.

Purpose of the Study:

  • To investigate the association between specific polymorphisms in CCL3 (rs1063340) and CCL4 (rs1049807) and HCV spontaneous clearance.
  • To evaluate the impact of these CCL3 and CCL4 polymorphisms on sustained virologic response (SVR) to pegylated interferon-alpha and ribavirin (pegIFN-α/RBV) treatment.

Main Methods:

  • Genotyping of two single nucleotide polymorphisms (SNPs), rs1063340 in CCL3 and rs1049807 in CCL4.
  • Analysis of HCV clearance in a general population of 1585 untreated individuals.
  • Assessment of SVR in a treatment cohort of 353 HCV patients receiving pegIFN-α/RBV therapy.

Main Results:

  • No significant association was found between the studied SNPs and spontaneous HCV clearance.
  • Variants rs1063340-C and rs1049807-G in CCL3 and CCL4, respectively, were associated with a reduced likelihood of achieving SVR (P=0.026 and P=0.048).
  • Ancestral alleles of both SNPs were linked to a 62% increased chance of viral clearance; glucose levels interacted with rs1063340's effect on SVR.

Conclusions:

  • Genetic variations in CCL3 and CCL4 may serve as predictive markers for HCV treatment outcomes.
  • These findings highlight the role of host genetics in modulating the response to antiviral therapy for HCV.
  • Further research is warranted to elucidate the precise mechanisms linking these SNPs to HCV SVR.
Abstract

Keywords:
CCL3CCL4ClearanceHepatitis C virusSVR

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