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Related Experiment Video

Updated: Feb 11, 2026

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Permanent Pacemaker Implantation After Rapid Deployment Aortic Valve Replacement.

Matthew A Romano1, Michael Koeckert2, Mubashir A Mumtaz3

  • 1Department of Cardiac Surgery, University of Michigan, Ann Arbor, Michigan.

The Annals of Thoracic Surgery
|April 30, 2018
PubMed
Summary
This summary is machine-generated.

Permanent pacemaker implantation (PPI) occurs in 13.6% of patients after rapid deployment aortic valve replacement. Risk factors include baseline conduction abnormalities, female gender, and larger valve size, with significant center-level variations observed.

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Area of Science:

  • Cardiovascular Surgery
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Rapid deployment aortic valves can disrupt the cardiac conduction system, necessitating permanent pacemaker implantation (PPI).
  • The Edwards Intuity valve system is a rapid deployment aortic valve used in aortic valve replacement procedures.

Purpose of the Study:

  • To characterize the incidence of PPI after aortic valve replacement using the Edwards Intuity valve system.
  • To identify patient-specific and procedural factors associated with PPI.

Main Methods:

  • Analysis of 708 patients from the TRANSFORM trial undergoing rapid deployment aortic valve replacement.
  • Recording of intrinsic conduction status and PPI incidence up to 1 year post-procedure.
  • Multivariate analysis to determine predictors of PPI.

Main Results:

  • The 30-day PPI incidence was 13.6%, with 10.9% attributed to atrioventricular block.
  • In patients without baseline conduction abnormalities, 30-day PPI was 8%.
  • Independent predictors for PPI included right bundle branch block, female gender, larger valve size, and atrioventricular block. Significant center-level differences in PPI rates were observed.

Conclusions:

  • Right bundle branch block, atrioventricular block, female gender, and larger valve size are associated with PPI after rapid deployment aortic valve replacement.
  • Center-level effects suggest variations in clinical practice may influence PPI rates.
  • Findings enhance understanding of PPI and guide clinical management for patients undergoing rapid deployment aortic valve replacement.