Related Experiment Video
Updated: Feb 11, 2026
04:33
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
1.5K
Rest-activity rhythm profiles associated with manic-hypomanic and depressive symptoms
Stephen F Smagula1, Robert T Krafty2, Julian F Thayer3
1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Journal of Psychiatric Research
|April 30, 2018
Summary
Rest-activity rhythm (RAR) disturbances are linked to mood disorders. Specific RAR profiles correlate with distinct psychiatric symptoms, offering insights into clinical heterogeneity.
Area of Science:
- Chronobiology
- Psychiatry
- Sleep Medicine
Background:
- Rest-activity rhythm (RAR) disturbances are increasingly recognized as potential biomarkers for mood disorders.
- Identifying specific RAR profiles associated with psychiatric symptom dimensions is crucial for understanding clinical heterogeneity.
Purpose of the Study:
- To identify distinct rest-activity rhythm (RAR) profiles using data-driven clustering.
- To evaluate the association between these empirically-derived RAR profiles and various psychiatric symptom dimensions.
Main Methods:
- 145 adults (aged 36-82) were analyzed using data-driven clustering to identify RAR profiles.
- Psychiatric symptom dimensions, including affect, depression, mania, panic, and substance use, were assessed and correlated with identified RAR profiles.
Main Results:
- Three RAR profiles emerged: 'earlier/robust,' 'later/irregular,' and 'later/narrower.'
- The 'later/irregular' group showed significantly higher lifetime manic-hypomanic and depressive symptoms compared to the 'earlier/robust' group.
- The 'later/narrower' group exhibited higher lifetime depressive symptoms than the 'earlier/robust' group, even after adjusting for sleep continuity and duration.
Conclusions:
- Distinct RAR profiles are associated with specific psychiatric symptom dimensions, highlighting their role in clinical heterogeneity.
- Objective assessment of RARs may offer opportunities for monitoring and intervention to improve mental health outcomes.
- Further longitudinal research is needed to determine if RAR characteristics predict manic/depressive episodes or result from psychiatric conditions.
More Related Videos
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
23.5K
18:08Assaying Locomotor Activity to Study Circadian Rhythms and Sleep Parameters in Drosophila
Published on: September 28, 2010
48.3K
Related Concept Videos
01:21The Resting Membrane Potential
143.1K
Overview
143.1K
01:05Long-term Depression
33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
03:12Freezing Point Depression and Boiling Point Elevation
40.4K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.4K
01:24Resting Membrane Potential
22.0K
The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
22.0K
01:15Resting Potential Decay
6.5K
The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane...
At rest, the K+ is the main ion that moves across the membrane...
6.5K
01:28Depressants
462
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
462