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Updated: Feb 11, 2026

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice
Published on: January 25, 2022
Peripheral nerve injuries, pain, and neuroplasticity
Natalie R Osborne1, Dimitri J Anastakis2, Karen D Davis2
1Krembil Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Peripheral nerve injuries (PNIs) alter brain structure and function, leading to sensorimotor deficits and pain. Understanding these neuroplastic changes is crucial for effective rehabilitation and improved patient outcomes.
Area of Science:
- Neuroscience
- Rehabilitation Medicine
Background:
- Peripheral nerve injuries (PNIs) induce structural and functional brain alterations.
- These changes are linked to sensorimotor abnormalities and chronic pain.
Purpose of the Study:
- To provide hand therapists an overview of neuroplasticity following PNIs.
- To explain brain changes during PNI, repair, and rehabilitation.
Main Methods:
- Review of neuroplasticity and neuroimaging principles.
- Discussion of sensory testing techniques for PNI patients.
Main Results:
- Detailed description of brain changes in traumatic and nontraumatic PNI recovery.
- Explanation of how neuroplasticity contributes to symptoms like hypoesthesia, hyperalgesia, and neurogenic pain.
- Impact of maladaptive neuroplasticity and psychological factors on treatment outcomes.
Conclusions:
- Understanding brain changes in PNI recovery can guide rehabilitation.
- Novel techniques targeting maladaptive brain changes may improve outcomes.
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