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Updated: Feb 11, 2026

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Does Googling lead to statin intolerance?

Sarah Khan1, Anne Holbrook2, Baiju R Shah3

  • 1Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

International Journal of Cardiology
|May 1, 2018
PubMed
Summary
This summary is machine-generated.

The nocebo effect, driven by online information, may explain high statin intolerance rates. More websites detailing statin side effects correlate with increased patient intolerance globally.

Keywords:
InternetNocebo effectStatins

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Area of Science:

  • Pharmacology
  • Health Communication
  • Psychosomatic Medicine

Background:

  • The nocebo effect, where negative expectations lead to adverse experiences, is a potential driver of observed statin intolerance.
  • Internet-based health information may significantly influence patient expectations and contribute to the nocebo effect.
  • High rates of statin intolerance in observational studies warrant investigation into contributing psychological and informational factors.

Purpose of the Study:

  • To investigate the association between the volume of online information on statin side effects and the prevalence of statin intolerance.
  • To determine if search engine results for statin side effects correlate with reported statin intolerance across different countries.

Main Methods:

  • A web-based survey of primary care physicians and specialists across 13 countries on 5 continents established statin intolerance prevalence.
  • Google searches in each country's native language quantified websites detailing statin side effects, standardized against overall statin websites.
  • Virtual private network (VPN) usage ensured country-specific search results, maintaining data integrity.

Main Results:

  • A strong positive correlation (r=0.868) was observed between the standardized number of websites about statin side effects and statin intolerance prevalence.
  • English-speaking countries exhibited the highest prevalence of statin intolerance and the greatest number of statin side effect-related websites.
  • Findings indicate a significant relationship between accessible online information on adverse effects and patient experience with statins.

Conclusions:

  • Increased availability of online information regarding statin side effects is strongly associated with higher rates of statin intolerance.
  • The nocebo effect, amplified by readily accessible online content, likely plays a substantial role in patient statin intolerance.
  • Healthcare providers and patients should be mindful of online information's potential impact on medication adherence and tolerability.