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Updated: Feb 11, 2026

Procurement and Perfusion-Decellularization of Porcine Vascularized Flaps in a Customized Perfusion Bioreactor
Published on: August 1, 2022
A compact instrument to measure perfusion of vasculature in transplanted maxillofacial free flaps
Noah J Kolodziejski1, Christopher J Stapels1, Daniel R McAdams1
1Radiation Monitoring Devices, Inc., 44 Hunt St., Watertown, MA, 02472 USA.
Abstract:
The vascularization and resulting perfusion of transferred tissues are critical to the success of grafts in buried free flap transplantations. To enable long-term clinical monitoring of grafted tissue perfusion during neovascularization and endothelialization, we are developing an implantable instrument for the continuous monitoring of perfusion using diffuse correlation spectroscopy (DCS), and augmented with diffuse reflectance spectroscopy (DRS). This work discusses instrument construction, integration, and preliminary results using a porcine graft model.
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