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Updated: Feb 11, 2026

Orthotopic Liver Transplantation in Rats
Published on: July 1, 2012
Dramatic change in cerebral oximetry during liver transplantation
Semhar J Ghebremichael1, Srikanth Sridhar1, Sara Guzman-Reyes1
1Department of Anesthesiology, University of Texas McGovern Medical School, Houston, Texas.
Abstract:
We report dramatic changes in bilateral cerebral tissue oxygenation in a patient undergoing an orthotopic liver transplant coincident with clamping and subsequent restoration of flow through the inferior vena cava. Although hemodynamic stability was maintained with low-dose vasopressor support, cardiac output was decreased, suggesting preload dependence of the measured cerebral oxygenation. Further investigation is warranted in patients with end-stage liver disease and interruption of venous return.
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