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MicroRNA and Microvascular Complications of Diabetes

F Barutta1, S Bellini1, R Mastrocola2

  • 1Laboratory of Diabetic Nephropathy, Department of Medical Sciences, University of Turin, Turin, Italy.

International Journal of Endocrinology
|May 1, 2018
PubMed

Insights

MicroRNAs (miRNAs) are implicated in diabetes complications affecting organs like the kidney and retina. These molecules show promise as noninvasive biomarkers for diagnosing and predicting these serious vascular issues.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • MicroRNAs (miRNAs) are increasingly recognized for their role in diabetes complications.
  • These small non-coding RNAs influence key pathogenic processes in microvascular injury.

Purpose of the Study:

  • To review the current understanding of miRNA involvement in diabetes-related microvascular damage.
  • To discuss the potential of miRNAs as diagnostic and prognostic biomarkers for these complications.

Main Methods:

  • Literature review of studies on miRNAs and diabetes microvascular complications.
  • Analysis of research on miRNA expression and function in affected tissues and circulation.

Main Results:

  • Abnormally expressed miRNAs are central to fibrosis, apoptosis, inflammation, and angiogenesis in diabetic microvascular disease.
  • Circulating miRNAs are emerging as potential noninvasive markers for early detection and monitoring.

Conclusions:

  • miRNAs play a critical role in the pathogenesis of diabetic microvascular complications.
  • miRNAs hold significant promise as novel, noninvasive biomarkers for clinical application in diabetes management.

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