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Effect of Chlorogenic Acid Intake on Cognitive Function in the Elderly: A Pilot Study
Morimasa Kato1, Ryuji Ochiai2, Kazuya Kozuma2
1Department of Health and Nutrition, Yamagata Prefectural Yonezawa University of Nutrition Sciences, Yonezawa 992-0025, Japan.
Summary
Daily intake of chlorogenic acids (CGAs) significantly improved cognitive functions, including memory and attention, in healthy older adults experiencing subjective memory loss over six months.
Area of Science:
- Neuroscience
- Nutritional Science
- Gerontology
Background:
- Subjective memory loss is a common concern in aging populations.
- Cognitive decline impacts daily functioning and quality of life.
- Dietary interventions are being explored to support cognitive health in the elderly.
Purpose of the Study:
- To investigate the impact of chlorogenic acids (CGAs) supplementation on cognitive performance.
- To assess changes in memory, attention, and executive functions following CGA intake.
Main Methods:
- A pilot study involving 8 healthy elderly participants with subjective memory loss.
- Participants consumed a beverage with 330 mg of CGAs before bedtime for 6 months.
- Cognitive function was evaluated using Cogstate and CNS Vital Signs test batteries.
Main Results:
- Significant improvements were noted in the One Back Test, Shifting Attention Test, and Finger Tapping Test.
- CNS Vital Signs revealed enhancements in composite memory, verbal memory, complex attention, cognitive flexibility, executive function, and motor speed.
- These cognitive benefits were observed after the 6-month intervention period.
Conclusions:
- Six months of daily chlorogenic acids (CGAs) intake may enhance cognitive functions in older adults.
- CGAs show potential as a dietary supplement to support attentional, executive, and memory functions.
- Further research is warranted to confirm these findings in larger populations.
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