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Related Concept Videos

Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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Related Experiment Video

Updated: Feb 11, 2026

Anterior Cervical Discectomy and Fusion in the Ovine Model
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Cervical exenteration.

Uma M Sachdeva1, Michael Lanuti1

  • 1Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, USA.

Annals of Cardiothoracic Surgery
|May 1, 2018
PubMed
Summary
This summary is machine-generated.

Cervical exenteration is a complex surgery for advanced cancers of the airway and esophagus. While risky, it offers a chance for cure or palliation in select patients.

Keywords:
Mediastinal tracheostomyaortic homograftconduitreconstructionskin flap

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Area of Science:

  • Surgical Oncology
  • Head and Neck Surgery
  • Thoracic Surgery

Background:

  • Cervical exenteration is a radical surgical procedure.
  • It is used for locally invasive cancers of the trachea, esophagus, thyroid, and recurrent tumors.
  • Occasionally indicated for benign conditions.

Purpose of the Study:

  • To describe the procedure, reconstruction methods, and potential complications of cervical exenteration.
  • To highlight its role in cancer treatment and palliation.

Main Methods:

  • Radical resection of larynx, pharynx, esophagus, and trachea.
  • Reconstruction of the alimentary tract using stomach or colon.
  • Management of potential complications like innominate artery erosion.

Main Results:

  • Significant risks include anastomotic leak, innominate artery erosion, and tracheostomy dehiscence.
  • Postoperative death is a potential outcome.
  • Functional results can be equivalent to total laryngectomy.

Conclusions:

  • Cervical exenteration is a high-risk procedure with considerable morbidity.
  • In carefully selected patients, it offers a unique opportunity for cure or palliation.
  • It can achieve functional outcomes comparable to less extensive surgeries.