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Morphometric Magnetic Resonance Imaging Study in Children With Primary Monosymptomatic Nocturnal Enuresis

Mengxing Wang1, Anyi Zhang2,3, Jilei Zhang1

  • 1Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai, China.

Frontiers in Pediatrics
|May 1, 2018
PubMed

Insights

Children with primary monosymptomatic nocturnal enuresis (PMNE) have brain structural differences. Specifically, increased gray matter volume in the frontal lobe and reduced gyrification in the precuneus were observed in affected children.

Area of Science:

  • Neuroscience
  • Pediatrics
  • Radiology

Background:

  • Primary monosymptomatic nocturnal enuresis (PMNE) is common in children.
  • Previous research indicated functional brain abnormalities in children with PMNE.
  • Limited studies have explored structural gray matter changes in PMNE.

Purpose of the Study:

  • To investigate brain structural changes in gray matter of children with PMNE.
  • Utilize magnetic resonance imaging (MRI) to compare gray matter volumes (GMVs) and gyrification indices (GIs) between children with PMNE and healthy controls.

Main Methods:

  • Structural MRI data were collected from 26 children with PMNE and 28 healthy children.
  • Voxel-based and surface-based morphometry analyses were performed to calculate GMVs and GIs.
  • Two-sample t-tests identified differences in GMV and GI between the two groups.

Main Results:

  • Children with PMNE exhibited significantly increased GMVs in the supplementary motor area and medial prefrontal cortex compared to controls.
  • Children with PMNE showed significantly reduced GIs in the right precuneus compared to controls.

Conclusions:

  • Children with PMNE demonstrate abnormal gray matter volumes in the frontal lobe.
  • Altered gyrification indices in the precuneus are also noted in children with PMNE.
  • These structural brain changes may contribute to the pathological mechanisms underlying PMNE.
Abstract

Keywords:
magnetic resonance imagingnocturnal enuresisprecuneusstructural changesupplementary motor area

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