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Photoactivation of imatinib-antibody conjugate using low-energy visible light from Ru(ii)-polypyridyl cages
Thomas N Rohrabaugh1, Ashley M Rohrabaugh, Jeremy J Kodanko
1Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA. turro.1@osu.edu.
Abstract:
Ru(ii)-polypyridyl cages with sterically bulky bidentate ligands provide efficient photochemical release of the anticancer drug imatinib using low energy visible light, imparting spatiotemporal control over drug bioavailability. The light-activated drug release is maintained when the Ru(ii) cage is covalently coupled to an antibody, which is expected to localize selectively on the tumor.
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