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Association between Parathyroid Hormone and Cardiovascular Disease

Hideki Fujii1

  • 1Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|May 1, 2018
PubMed

Insights

Parathyroid hormone impacts cardiovascular health beyond calcium and phosphate regulation. Controlling parathyroid hormone levels is crucial, particularly for chronic kidney disease patients, to reduce cardiovascular risks.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Nephrology

Background:

  • Parathyroid hormone (PTH) is primarily known for calcium and phosphate metabolism.
  • Emerging evidence links PTH to cardiovascular system effects, including heart and vessels.
  • The detailed pathophysiological mechanisms underlying PTH's cardiovascular impact are not fully understood.

Purpose of the Study:

  • To explore the association between parathyroid hormone and cardiovascular events.
  • To investigate the potential mechanisms linking PTH to cardiovascular disease.
  • To emphasize the importance of PTH level control in patient management.

Main Methods:

  • Review of clinical studies investigating PTH levels and cardiovascular outcomes.
  • Analysis of proposed pathophysiological pathways involving the renin-angiotensin-aldosterone system.
  • Consideration of PTH's direct effects on cardiovascular structures.

Main Results:

  • Clinical studies associate elevated PTH with increased cardiovascular events and mortality.
  • This association is observed in both patients with and without chronic kidney disease.
  • Potential mechanisms include interaction with the renin-angiotensin-aldosterone system and direct cardiovascular effects.

Conclusions:

  • Parathyroid hormone plays a significant role in cardiovascular health.
  • Controlling serum PTH levels is as important as managing calcium and phosphate.
  • Particular attention to PTH control is warranted in patients with chronic kidney disease to mitigate cardiovascular risks.

Keywords:
AldosteroneCardiovascular DiseaseChronic Kidney DiseaseParathyroid HormoneRenin-angiotensin-Aldosterone System

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