Related Experiment Video
Updated: Feb 11, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.5K
Systemic Monotherapy Treatments for Generalized Pustular Psoriasis: A Systematic Review
Linghong Linda Zhou1, Jorge R Georgakopoulos2, Arvin Ighani3
11 Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Journal of Cutaneous Medicine and Surgery
|May 1, 2018
Summary
Generalized pustular psoriasis (GPP) is a severe skin condition. This review evaluates systemic monotherapies, finding retinoids and biologics promising but needing more evidence for GPP treatment.
Area of Science:
- Dermatology
- Clinical Pharmacology
Background:
- Generalized pustular psoriasis (GPP) is a rare, severe dermatosis with significant morbidity and mortality.
- Current treatment lacks a standardized algorithmic approach, and evidence quality is often limited.
Purpose of the Study:
- To review and evaluate the evidence for systemic monotherapies in treating GPP.
- To assess the efficacy, safety, and tolerability of available treatment options.
Main Methods:
- A comprehensive literature search was performed using MEDLINE, EMBASE, and PubMed.
- 31 clinical studies on systemic monotherapy for GPP were included in the review.
Main Results:
- Treatment modalities evaluated included retinoids, cyclosporine, biologics, and dapsone.
- Retinoids are among the best-supported options; biologics show emerging potential.
- No high-quality evidence or established treatment algorithm currently exists for GPP.
Conclusions:
- Systemic retinoids, cyclosporine, biologics, and dapsone can be considered first-line agents for GPP.
- Treatment decisions must be individualized based on patient-specific factors.
- Further research is needed, particularly for biologic therapies.
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