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Recent Progress of Marine Polypeptides as Anticancer Agents.

Lanhong Zheng1, Yixin Xu1, Xiukun Lin2

  • 1School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.

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Marine peptides offer diverse anticancer potential for drug discovery. Recent patents highlight their mechanisms, showing promise as novel cancer therapies.

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Area of Science:

  • Marine biotechnology and drug discovery
  • Peptide-based therapeutics
  • Oncology and cancer research

Background:

  • The marine environment is a vast reservoir for novel anticancer drug discovery.
  • Marine organisms' biodiversity yields rich sources for anticancer peptides.
  • Marine peptides present new opportunities for developing cancer therapeutics.

Purpose of the Study:

  • To review recent advancements in patented marine anticancer peptides.
  • To elucidate the structures and anticancer mechanisms of these peptides.
  • To provide insights into their therapeutic potential in cancer treatment.

Main Methods:

  • Review of patents (2010-2018) on marine anticancer peptides.
  • Analysis of peptide targets within various cellular signal pathways.
  • Discussion of mechanisms including apoptosis induction, tubulin-microtubule effects, angiogenesis, and kinase activity.

Main Results:

  • Compilation of recent patented marine peptides with demonstrated anticancer activity.
  • Detailed discussion on the mechanisms of action and molecular diversity of these peptides.
  • Correlation of peptide activity with specific anticancer properties and pharmacological effects.

Conclusions:

  • Marine peptides exhibit significant chemical diversity and potent anticancer effects.
  • These peptides effectively target multiple cancer-related signal pathways.
  • Marine peptides show considerable promise for development into novel anticancer agents.