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Bronchoconstriction by nebulized metabisulfite solutions (SO2) and its modification by ipratropium bromide
J P Seale1, D M Temple, C M Tennant
1Department of Pharmacology, University of Sydney, New South Wales, Australia.
Annals of Allergy
|September 1, 1988
Abstract:
A nebulized solution of sodium metabisulfite (MBS) induced bronchoconstriction in nine subjects with asthma. An anticholinergic drug, ipratropium bromide (IPRA), in doses (500 to 700 micrograms) which were found to inhibit methacholine-induced bronchoconstriction, protected three of the nine subjects against nebulized MBS. These results suggest that both cholinergic and non-cholinergic reflex mechanisms are involved in MBS-induced bronchoconstriction.