Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

51.8K
Overview
51.8K
Cancer Vaccines01:30

Cancer Vaccines

1.1K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K
Sustainable Development01:43

Sustainable Development

15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
Language Development01:22

Language Development

925
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
925
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.1K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.1K
Development of Immunocompetence01:22

Development of Immunocompetence

982
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
982

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The glycosomal alkyl-dihydroxyacetonephosphate synthase TbADS is essential for the synthesis of ether glycerophospholipids in procyclic trypanosomes.

Experimental parasitology·2018
Same author

Lipidomics and anti-trypanosomatid chemotherapy.

Clinical and translational medicine·2017
Same author

The Trypanosoma brucei dihydroxyacetonephosphate acyltransferase TbDAT is dispensable for normal growth but important for synthesis of ether glycerophospholipids.

PloS one·2017
Same author

The Glycerol-3-Phosphate Acyltransferase TbGAT is Dispensable for Viability and the Synthesis of Glycerolipids in Trypanosoma brucei.

The Journal of eukaryotic microbiology·2016
Same author

In Vitro Assay to Measure Phosphatidylethanolamine Methyltransferase Activity.

Journal of visualized experiments : JoVE·2016
Same author

Characterization of Leishmania major phosphatidylethanolamine methyltransferases LmjPEM1 and LmjPEM2 and their inhibition by choline analogs.

Molecular and biochemical parasitology·2014

Related Experiment Video

Updated: Feb 11, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

22.6K

Cutaneous Leishmaniasis: Update on Vaccine Development.

Davian C Whyte1, Rachel Zufferey1

  • 1Department of Biological Sciences, St. John's University, Queens, NY, USA.

Human Parasitic Diseases (Auckland, N.Z.)
|May 1, 2018
PubMed
Summary

Developing a safe and effective vaccine is crucial for treating and preventing leishmaniasis, a widespread parasitic disease. This review highlights recent vaccine advancements and future research directions for cutaneous leishmaniasis.

Keywords:
Cutaneous leishmaniasisimmunotherapyvaccine

More Related Videos

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells
10:03

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

17.6K
Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
11:35

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Published on: December 8, 2010

17.0K

Related Experiment Videos

Last Updated: Feb 11, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

22.6K
Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells
10:03

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

17.6K
Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
11:35

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Published on: December 8, 2010

17.0K

Area of Science:

  • Parasitology
  • Infectious Diseases
  • Vaccinology

Background:

  • Leishmaniasis is a significant protozoan disease transmitted by sandflies, endemic in tropical/subtropical areas.
  • Cutaneous leishmaniasis, the most common form, affects over 10 million globally, with 1.5 million new cases annually.
  • Current chemotherapy is suboptimal, facing challenges with drug resistance and vector control, necessitating vaccine development.

Purpose of the Study:

  • To review recent progress in developing safe and effective vaccines for cutaneous leishmaniasis.
  • To discuss vaccine candidates for both prevention and treatment of the disease.
  • To provide an outlook on future research in leishmaniasis vaccine development.

Main Methods:

  • Review of recent scientific literature on leishmaniasis vaccine research.
  • Analysis of advancements in vaccine development strategies.
  • Synthesis of findings related to vaccine safety and efficacy.

Main Results:

  • Several vaccine candidates show promise for preventing and treating cutaneous leishmaniasis.
  • Recent research focuses on novel approaches to overcome challenges in vaccine development.
  • Progress has been made in identifying potential vaccine targets and platforms.

Conclusions:

  • A safe and effective vaccine is urgently needed to combat leishmaniasis.
  • Recent advances offer hope for improved prevention and treatment strategies.
  • Continued research is essential to translate promising candidates into viable vaccines.