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Updated: Feb 11, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
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Long Non-coding RNAs as Regulators of the Mitogen-activated Protein Kinase (MAPK) Pathway in Cancer

Behnoosh Tasharrofi, Soudeh Ghafouri-Fard1

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti
|May 1, 2018
PubMed
Abstract

Insights

Long non-coding RNAs (lncRNAs) regulate the mitogen-activated protein kinase (MAPK) pathway, impacting cell functions and cancer development. Identifying lncRNAs offers potential for novel cancer biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Gene Regulation

Background:

  • The mitogen-activated protein kinase (MAPK) pathway controls critical cellular functions including proliferation, differentiation, migration, and apoptosis.
  • Key MAPK pathway components include extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), p38, and ERK5.
  • This complex signaling network is influenced by external stimuli and crosstalk with other pathways, playing a significant role in malignant phenotypes.

Purpose of the Study:

  • To investigate the regulatory role of long non-coding RNAs (lncRNAs) within the MAPK signaling pathway.

Main Methods:

  • Literature review and analysis of existing research on lncRNAs and MAPK signaling.
  • Exploration of lncRNA-mediated gene expression regulation at transcriptional and post-transcriptional levels.
  • Examination of lncRNA involvement in pathway crosstalk and potential therapeutic applications.

Main Results:

  • Altered lncRNA expression impacts MAPK pathway activity, influencing apoptosis, cell proliferation, and migration in cancer.
  • Specific lncRNAs engage in cross-talk with other cancer-related pathways, such as PI3K/Akt, by modulating shared proteins.
  • lncRNAs demonstrate potential as biomarkers for cancer and as targets for novel therapeutic strategies.

Conclusions:

  • lncRNAs are crucial regulators of the MAPK pathway and its role in cancer pathogenesis.
  • Understanding lncRNA-MAPK interactions can lead to the development of effective cancer therapies.
  • lncRNA signatures may serve as valuable biomarkers for cancer diagnosis and treatment monitoring.

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