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Related Experiment Video

Updated: Feb 11, 2026

Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer
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BRAF-mutant colorectal cancer, a different breed evolving.

Eleonora Lai1,2, Andrea Pretta1,2, Valentino Impera1,2

  • 1a Medical Oncology , Sapienza-University of Rome , Rome , Italy.

Expert Review of Molecular Diagnostics
|May 1, 2018
PubMed
Summary

BRAF-mutant colorectal cancer (BRAF MT CRC) presents unique challenges and a poor prognosis. Research is ongoing to define the predictive value of BRAF mutations and optimize treatments, including targeted therapies and chemotherapy combinations.

Keywords:
BRAFBRAF inhibitorscolorectal cancerpredictive valueprognostic value

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Area of Science:

  • Oncology
  • Molecular Pathology
  • Gastroenterology

Background:

  • BRAF-mutant colorectal cancer (BRAF MT CRC) is a distinct subtype with poor prognosis.
  • Standard treatment and the full predictive value of BRAF mutations remain undefined.
  • BRAFV600E mutation is a significant negative prognostic factor in specific colorectal cancer stages.

Purpose of the Study:

  • To review the prognostic and predictive value of BRAF mutational status in colorectal cancer.
  • To discuss current and emerging treatment strategies for BRAF MT CRC.
  • To explore future clinical and translational research directions, including combination therapies.

Main Methods:

  • Literature review using PubMed with keywords: 'BRAF mutation', 'colorectal cancer', 'predictive and prognostic value', 'targeted therapy', 'BRAF inhibition'.
  • Analysis of BRAF mutations beyond BRAFV600E.
  • Discussion of current treatment standards and future therapeutic avenues.

Main Results:

  • BRAFV600E mutation is a strong, independent negative prognostic indicator in stage II-III MSS CRC and metastatic CRC (mCRC).
  • Optimal treatment for BRAF MT CRC is yet to be established.
  • Intensive chemotherapy combinations are the current standard of care for eligible patients.

Conclusions:

  • BRAF MT CRC requires further investigation to improve patient outcomes.
  • Combination therapies targeting the RAS/RAF/MEK/ERK pathway alongside chemotherapy show promise for overcoming resistance.
  • Defining optimal therapeutic strategies is crucial for this challenging patient subgroup.