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Oxygen supplementation for critically ill patients-A protocol for a systematic review
M Barbateskovic1,2, O L Schjørring2,3, J C Jakobsen2,4,5
1Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Copenhagen, Denmark.
Acta Anaesthesiologica Scandinavica
|May 1, 2018
Summary
This systematic review evaluates randomized trials on oxygen therapy for critically ill patients. It aims to determine if higher or lower oxygen levels impact patient outcomes, addressing a gap in current clinical guidelines.
Area of Science:
- Critical Care Medicine
- Respiratory Physiology
- Evidence-Based Medicine
Background:
- Hypoxemia is common in critically ill patients, often treated with supplemental oxygen.
- Excessive oxygen (hyperoxia) may cause harm, as suggested by observational studies.
- Current guidelines recommend oxygen despite limited high-quality evidence.
Purpose of the Study:
- To systematically review randomized clinical trials (RCTs) on oxygen therapy in critically ill adults.
- To compare the effects of higher versus lower inspiratory oxygen fractions or arterial oxygen targets.
- To provide evidence to inform clinical practice and future research on oxygen administration.
Main Methods:
- Comprehensive search of major international databases for RCTs.
- Independent screening, data extraction, and quality assessment (Cochrane risk of bias tool) by two authors.
- Data analysis using Review Manager and Trial Sequential Analysis, with GRADE assessment for evidence quality.
Main Results:
- This section is to be populated upon study completion.
Conclusions:
- This systematic review will provide reliable evidence on the efficacy and safety of different oxygen strategies in critically ill patients.
- Findings will inform clinical decision-making and guide the design of future trials.
- Addresses a critical knowledge gap regarding optimal oxygenation targets in intensive care settings.
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