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Economic and clinical burden of viral hepatitis in California: A population-based study with longitudinal analysis

Haesuk Park1, Donghak Jeong2, Pauline Nguyen2

  • 1University of Florida College of Pharmacy, Pharmaceutical Outcomes & Policy, Gainesville, FL, United States of America.

Plos One
|May 1, 2018
PubMed

Insights

Hepatitis B virus (HBV) patients faced higher hospitalization costs than Hepatitis C virus (HCV) patients. While HBV patients had a slightly lower mortality rate, their causes and locations of death differed significantly from HCV patients.

Area of Science:

  • Hepatology
  • Public Health
  • Health Economics

Background:

  • The economic burden associated with Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) infections is increasing.
  • Understanding the comparative financial and mortality impact of HBV versus HCV is crucial for resource allocation and patient management.

Purpose of the Study:

  • To compare hospital admission rates, charges, mortality rates, and causes of death between Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) patients within a US population.
  • To analyze the economic and survival outcomes associated with HBV and HCV infections.

Main Methods:

  • A retrospective cohort analysis was conducted using the California Office of Statewide Health Planning and Development database from 2006 to 2013.
  • Data from 23,891 HBV patients and 148,229 HCV patients were analyzed to compare key health and economic outcomes.

Main Results:

  • Hepatitis B virus (HBV) patients incurred significantly higher liver-related hospital charges per person per year compared to Hepatitis C virus (HCV) patients ($123,239 vs $111,837).
  • Across the 8-year study period, HBV patients showed a higher mean increase in all-cause and liver-related hospitalization charges compared to HCV patients.
  • While the adjusted mortality hazard ratio was slightly lower for HBV patients (0.96), the major causes of death differed, with HBV patients more frequently dying from other malignant neoplasms (35%) compared to HCV patients (20%).

Conclusions:

  • Hepatitis B virus (HBV) infection is associated with greater liver-related hospital charges and a higher overall increase in hospitalization costs over time compared to Hepatitis C virus (HCV).
  • Although HBV patients experienced slightly lower mortality rates, their patterns of death, including causes and place of death, were distinct from those of HCV patients.
  • These findings highlight the significant and differing economic and survival impacts of HBV and HCV infections, necessitating tailored public health and clinical strategies.
Abstract

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