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Related Concept Videos

MicroRNAs01:22

MicroRNAs

24.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
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Updated: Feb 11, 2026

MicroRNA-based Regulation of Picornavirus Tropism
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[Mechanoresponsive microRNA].

Yang Wang, Yong Guo

    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
    |May 1, 2018
    PubMed
    Summary

    Mechanoresponsive microRNAs (miRNAs) change expression with mechanical strain, impacting cell function. This review summarizes current findings on these crucial miRNAs and suggests future research directions for clinical applications.

    Area of Science:

    • Molecular Biology
    • Biomedical Engineering
    • Genetics

    Background:

    • Mechanoresponsive microRNAs (miRNAs) are critical regulators of cellular responses to mechanical stimuli.
    • Their expression levels are altered by mechanical loading, influencing downstream mRNA and protein targets.
    • Existing discoveries of mechanoresponsive miRNAs are often limited and lack direct clinical applicability.

    Purpose of the Study:

    • To comprehensively review current research on mechanoresponsive miRNAs.
    • To highlight the significance of these miRNAs in physiological and pathological contexts.
    • To provide insights for future clinical practice and research avenues.

    Main Methods:

    • Literature review and synthesis of existing studies on mechanoresponsive miRNAs.

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  • Analysis of miRNA expression changes in response to mechanical strain.
  • Evaluation of the functional impact of mechanoresponsive miRNAs on cellular processes.

    • Main Results:

    • Identification and characterization of various mechanoresponsive miRNAs across different tissues.
    • Demonstration of altered miRNA expression profiles under diverse mechanical loading conditions.
    • Evidence linking mechanoresponsive miRNAs to disease pathogenesis and progression.

    Conclusions:

    • Mechanoresponsive miRNAs represent a significant class of regulatory molecules with potential therapeutic targets.
    • Further research is needed to translate current findings into effective clinical strategies.
    • Understanding mechanoresponsive miRNAs can advance personalized medicine and regenerative therapies.