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Updated: Feb 11, 2026

The Extraction of Liver Glycogen Molecules for Glycogen Structure Determination

The Extraction of Liver Glycogen Molecules for Glycogen Structure Determination

Published on: February 8, 2022

Glycogenic hepatopathy.

Johad Khoury¹, Yaniv Zohar², Naim Shehadeh³

¹Internal Medicine B, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Liver Unit, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Hepatobiliary & Pancreatic Diseases International : HBPD INT

|May 1, 2018

Summary

This summary is machine-generated.

Glycogenic hepatopathy (GH) is a liver disorder linked to diabetes. Diagnosis can be made without liver biopsy by evaluating clinical signs, tests, and treatment response.

Keywords:

Diabetes mellitus Glycogenic hepatopathy Hepatic glycogenosis Mauriac syndrome

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Area of Science:

Hepatology
Endocrinology
Internal Medicine

Background:

Glycogenic hepatopathy (GH) is a liver condition associated with uncontrolled diabetes mellitus, primarily type 1.
Clinical manifestations include right upper quadrant pain, hepatomegaly, and elevated liver enzymes, often making diagnosis challenging.
While liver biopsy is the gold standard, GH can be suspected based on clinical presentation and imaging.

Purpose of the Study:

To increase awareness of Glycogenic hepatopathy.
To propose an investigative pathway to reduce unnecessary and invasive tests.
To highlight conservative diagnostic approaches for GH.

Main Methods:

A literature search was conducted on PubMed using keywords related to glycogenic hepatopathy and diabetes.
Articles describing liver glycogen accumulation associated with diabetes mellitus were included.
The review synthesized findings from 47 articles detailing 126 patients with GH.

Main Results:

Hepatocellular injury was more prominent than cholestatic disturbance in patients with GH.
No instances of synthetic liver failure were reported in the reviewed cases.
The data suggests that GH typically resolves with improved glycemic control.

Conclusions:

Glycogenic hepatopathy can be diagnosed conservatively using medical history, physical examination, lab tests, imaging, and treatment response, potentially avoiding liver biopsy.
Liver biopsy should be considered only if diagnostic uncertainty persists or clinical response to treatment is lacking.
Noninvasive tests like FibroScan or FibroTest are not recommended for diagnosing GH or differentiating it from nonalcoholic fatty liver disease.