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Potential of siRNA-albumin complex against cancer

Na Liu1, Yan-Hua Qi1, Chuan-Tao Cheng2

  • 1Department of Ultrasound, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.

Chemico-Biological Interactions
|May 1, 2018
PubMed

Insights

Albumin effectively delivers small interfering RNA (siRNA) to colon cancer tumors in rats. This targeted delivery of siRNA for vascular endothelial growth factor receptor 2 (VEGF R2) shows promise for cancer therapy.

Area of Science:

  • Molecular Oncology
  • Gene Therapy
  • Nanomedicine

Background:

  • RNA interference (RNAi) is a potent gene therapy tool.
  • Developing tumor-selective delivery systems for siRNA is crucial for cancer treatment.
  • Targeting VEGF R2 is a key strategy in inhibiting tumor growth.

Purpose of the Study:

  • To develop a stable, tumor-selective delivery system for siRNA using albumin.
  • To evaluate albumin as a carrier for siRNA in a colon cancer model.
  • To assess the diagnostic and therapeutic potential of this siRNA delivery system.

Main Methods:

  • A colon cancer model was established in 20 male Wistar rats.
  • Albumin was used as a carrier molecule for siRNA targeting VEGF R2.
  • siRNA-albumin complexes were labeled with 99mTc for tracking delivery.

Main Results:

  • Efficient delivery of siRNA to the tumor site was confirmed via 99mTc labeling.
  • A significant decline in VEGF expression was observed post-siRNA delivery.
  • Albumin demonstrated effective tumor-selective delivery of siRNA.

Conclusions:

  • Albumin is a suitable and efficient carrier for targeted siRNA delivery in cancer therapy.
  • This approach holds potential for both diagnostic and therapeutic applications in oncology.
  • Targeted delivery of VEGF R2 siRNA using albumin can inhibit tumor progression.
Keywords:
(99m)TcAlbuminColon cancersiRNA

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