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Outcome of patients with psychogenic nonepileptic seizures with limited resources: A longitudinal study

Ali A Asadi-Pooya1, Fateme Ziyaee2

  • 1Neurosciences Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.

Seizure
|May 1, 2018
PubMed

Insights

Over half of patients with psychogenic nonepileptic seizures (PNES) achieved seizure freedom. Factors like lower education and psychiatric issues impacted outcomes, highlighting the need for better treatment access and research in Iran.

Area of Science:

  • Neurology
  • Psychiatry
  • Clinical Outcomes

Background:

  • Psychogenic nonepileptic seizures (PNES) are a functional neurological disorder.
  • Understanding long-term outcomes and associated factors is crucial for patient management.
  • Limited data exists on PNES outcomes specifically within the Iranian population.

Purpose of the Study:

  • To investigate the long-term seizure outcome of patients diagnosed with PNES in Iran.
  • To identify factors potentially influencing the seizure outcome in this patient cohort.

Main Methods:

  • A cohort of 86 patients with confirmed PNES, admitted between 2008-2013, was retrospectively identified.
  • A phone interview in 2017 assessed seizure freedom, psychotherapy history, and session count.
  • Statistical analysis explored associations between patient characteristics and seizure outcome.

Main Results:

  • 54.7% of patients achieved seizure freedom in the 12 months prior to the interview.
  • 86% of patients did not receive appropriate psychotherapy post-diagnosis.
  • Seizure freedom was associated with younger age at onset, higher education, and not taking psychiatric drugs.

Conclusions:

  • Despite limited treatment resources in Iran, a majority of PNES patients experienced seizure freedom.
  • Lower educational attainment, comorbid psychiatric conditions, and later age at seizure onset may negatively impact outcomes.
  • Future research should focus on multi-center, cross-cultural studies, considering broader outcome measures beyond seizure frequency.
Abstract

Keywords:
OutcomePNESPsychogenicSeizureVideo-EEG

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