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Updated: Feb 11, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
A repeat offender: Recurrent extraintestinal Clostridium difficile infection following fecal microbiota
Bradley J Gardiner1, Cheleste M Thorpe2, Nicholas V Pinkham3
1Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, USA.
Abstract:
Extraintestinal infection with Clostridium difficile has been reported but remains uncommon. Treatment of this unusual complication is complex given the limitations of current therapeutic options. Here we report a novel case of recurrent extraintestinal C. difficile infection that occurred following fecal microbiota transplantation. Using whole genome sequencing, we confirmed recrudescence rather than reinfection was responsible. The patient ultimately responded to prolonged, targeted antimicrobial therapy informed by susceptibility testing.
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